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Type  MGI:General Description  protease resistant Prnp deposits are found in many parts of the brain in mice suffering from neurological disease Prnp deposits ranged from diffuse synaptic-type depositions prominent in the hippocampus to plaque-like depositions in the reticular thalamic nucleus, the corpus callosum, the external and internal capsule, the cingulated cortex, and the anterior commissure nuclei depositions do not contain amyloid fibrils