Primary Identifier | MGI:2178124 | Allele Type | Targeted |
Gene | Gria2 | Transmission | Germline |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Point mutations were introduced that altered the Q/R edited codon from one encoding glutamate to one encoding arginine (R). A loxP flanked neomycin resistance cassette was inserted into intron 11, 5' to the ECS site. Gria2 (GluR-B) gene expression is reduced by 30% compared to wild-type. |