| First Author | Flaishon L | Year | 2004 |
| Journal | Blood | Volume | 104 |
| Issue | 4 | Pages | 933-41 |
| PubMed ID | 15126315 | Mgi Jnum | J:92638 |
| Mgi Id | MGI:3054155 | Doi | 10.1182/blood-2003-11-4013 |
| Citation | Flaishon L, et al. (2004) Expression of the chemokine receptor CCR2 on immature B cells negatively regulates their cytoskeletal rearrangement and migration. Blood 104(4):933-41 |
| abstractText | Immature B cells are targeted to specific areas in the spleen, where a fraction of these cells receive signals that induce them to mature and participate in the immune response. In this study, we show that the C-C chemokine receptor 2 (CCR2) is transcribed in immature B cells, while its message is dramatically down-regulated at the mature stage. CCR2-deficient cells exhibit up-regulation of chemokine-induced actin polymerization, migration, and homing to the lymph nodes of immature B cells. In addition, we demonstrate that control of homing by CCR2 is mediated by its ligand, CCL2/JE, which is secreted by B cells and down-regulates the stromal derived factor-1 (SDF-1) signaling cascade. Thus, this study describes an additional, previously uncharacterized, role for CCR2 and its ligand as negative regulators of the homing of immature B cells. |
