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Publication : Evolutionarily conserved, alternative splicing of reelin during brain development.

First Author  Lambert de Rouvroit C Year  1999
Journal  Exp Neurol Volume  156
Issue  2 Pages  229-38
PubMed ID  10328932 Mgi Jnum  J:54649
Mgi Id  MGI:1335663 Doi  10.1006/exnr.1999.7019
Citation  Lambert de Rouvroit C, et al. (1999) Evolutionarily conserved, alternative splicing of reelin during brain development. Exp Neurol 156(2):229-38
abstractText  Reelin is the protein defective in reeler mutant mice and plays a pivotal role in brain development. However, some uncertainties remain about the relationship between reelin and the reeler phenotype. It is generally believed that reelin, secreted by specific neuronal types such as Cajal-Retzius cells, acts at short distance via the extracellular matrix on target neurons, the response of which requires the Dab1 gene product. However, the pattern of reelin expression in some structures such as olfactory bulb, retina, and spinal cord suggests that the protein might be endowed with different functions. In the present study, we identify two uncommon, evolutionarily conserved splicing events in the 3' part of the transcript that result in different forms of the protein. First, a 6-nucleotide, brain-specific microexon is skipped in about 10% of reelin RNA. In addition, an alternative polyadenylation event involving 10-25% of reelin mRNA results in secretion of a truncated protein lacking the terminal, highly basic stretch. This alternative reelin is generally expressed in the same cells as the major form, but is almost undetectable in retina and spinal cord. Both alternative splicing events are present in mouse, rat, and man, suggesting that the corresponding reelin forms are functionally important. Copyright 1999 Academic Press.
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