| First Author | Mukhopadhyay A | Year | 2003 |
| Journal | Dev Dyn | Volume | 227 |
| Issue | 4 | Pages | 578-86 |
| PubMed ID | 12889067 | Mgi Jnum | J:84923 |
| Mgi Id | MGI:2670813 | Doi | 10.1002/dvdy.10332 |
| Citation | Mukhopadhyay A, et al. (2003) Embryonic stem cell and tissue-specific expression of a novel conserved gene, asrij. Dev Dyn 227(4):578-86 |
| abstractText | We have identified a novel gene expressed in murine embryonic stem (ES) cells and in a restricted, tissue-specific pattern during mouse development. The gene is also expressed in blood vessels; hence, we have named it asrij (Sanskrit; asRij= blood). The gene encodes a novel conserved, predicted transmembrane protein of 247 amino acids, which is localized to lysosomes and endosomes. During ES cell-derived blood vessel formation in vitro, Asrij expression precedes and partially overlaps with the vascular markers Flk-1 and PECAM. During development, Asrij is expressed predominantly in mouse embryonic blood vessels. The asrij transcript is alternatively spliced, and its expression is regulated in a tissue-specific manner. An asrij splice variant that is enriched in the adult mouse brain encodes a protein of 196 amino acids. Asrij can serve as an early stem cell marker that is down-regulated in nonvascular tissues. Our data indicate that Asrij belongs to a novel class of conserved proteins with a complex developmental profile and suggests multiple functions for the gene. |
