| Primary Identifier | MGI:2150920 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 116701 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Acts upstream of or within several processes, including diaphragm development; heart development; and skeletal system development. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; musculoskeletal system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1). PHENOTYPE: Homozygotes for a null allele show neonatal death due to respiratory distress, a malformed diaphragm, and lack of metanephric kidneys. Homozygotes for a different null allele show both fetal and neonatal death, a similar diaphragm defect, as well as cardiac and skeletal defects, and fetal anemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
