| Primary Identifier | MGI:1352629 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 20927 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables ADP binding activity and ATP binding activity. Involved in negative regulation of insulin secretion and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within several processes, including action potential; glutamate secretion, neurotransmission; and neuromuscular process. Part of protein-containing complex. Is active in plasma membrane. Is expressed in cerebral cortex; foregut-midgut junction; heart ventricle; and retina inner nuclear layer. Used to study hyperinsulinemic hypoglycemia and transient neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and hypertension. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). PHENOTYPE: Homozygotes for targeted null mutations exhibit a transient neonatal hypoglycemia and a late-developing glucose intolerance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
