| Type | MGI:General | Description | in a 2-step (DMBA/TPA) skin carcinogenesis protocol, all (18 of 18) mice develop slowly growing skin melanomas with an average of 12 cutaneous melanomas DMBA/TPA-induced melanomas involve the epidermo-dermal junction and show vertical invasive growth into the dermis; however, no proliferative activity of melanoma cells is detected by Ki67 staining 10 of 18 DMBA/TPA-treated mice also develop large subcutaneous cystic tumors filled with serous liquid and have to be sacrificed by 30 weeks of age all DMBA/TPA-treated mice develop on average 3 papillomas in the skin; these appear early after carcinogen treatment |
