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Allele : Bmf<tm3.1Rjd> BCL2 modifying factor; targeted mutation 3.1, Roger J Davis

Primary Identifier  MGI:4421180 Allele Type  Targeted
Attribute String  Not Specified Gene  Bmf
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed neo cassette was inserted within intron 3, and specific nucleotide mutations in exon 3 were introduced by homologous recombination. Mutation resulted in the JNK protein kinase phosphorylation site (Ser-74) in exon 3 to be substituted with an Ala (S74A). The neo cassette was then excised with Cre mediated recombination leaving a single loxP site in intron 3.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Bmf<S74A>,
  • Bmf<SA>,
  • Bmf<S74A>,
  • Bmf<SA>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

3 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele