| First Author | Pan Y | Year | 2018 |
| Journal | J Neurochem | Volume | 144 |
| Issue | 1 | Pages | 81-92 |
| PubMed ID | 29105065 | Mgi Jnum | J:253343 |
| Mgi Id | MGI:6102978 | Doi | 10.1111/jnc.14249 |
| Citation | Pan Y, et al. (2018) Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets. J Neurochem 144(1):81-92 |
| abstractText | Lower levels of the cognitively beneficial docosahexaenoic acid (DHA) are often observed in Alzheimer''s disease (AD) brains. Brain DHA levels are regulated by the blood-brain barrier (BBB) transport of plasma-derived DHA, a process facilitated by fatty acid-binding protein 5 (FABP5). This study reports a 42.1 +/- 12.6% decrease in the BBB transport of (14) C-DHA in 8-month-old AD transgenic mice (APPswe,PSEN1E9) relative to wild-type mice, associated with a 34.5 +/- 6.7% reduction in FABP5 expression in isolated brain capillaries of AD mice. Furthermore, short-term spatial and recognition memory deficits were observed in AD mice on a 6-month n-3 fatty acid-depleted diet, but not in AD mice on control diet. This intervention led to a dramatic reduction (41.5 +/- 11.9%) of brain DHA levels in AD mice. This study demonstrates FABP5 deficiency and impaired DHA transport at the BBB are associated with increased vulnerability to cognitive deficits in mice fed an n-3 fatty acid-depleted diet, in line with our previous studies demonstrating a crucial role of FABP5 in BBB transport of DHA and cognitive function. |
