| First Author | Schepart BS | Year | 1986 |
| Journal | J Immunol | Volume | 136 |
| Issue | 9 | Pages | 3489-95 |
| PubMed ID | 3082989 | Mgi Jnum | J:50654 |
| Mgi Id | MGI:1309392 | Doi | 10.4049/jimmunol.136.9.3489 |
| Citation | Schepart BS, et al. (1986) The nucleotide sequence and comparative analysis of the H-2Dp class I H-2 gene. J Immunol 136(9):3489-95 |
| abstractText | We present the complete nucleotide sequence and the deduced amino acid sequence of the H-2Dp class I gene. This gene, which was cloned from a B10.P genomic DNA library, encodes and intact, functional H-2Dp molecule. Comparative analysis of the Dp sequence with other class I sequences reveals both similarities and differences. This analysis also shows that these genes exhibit D region-specific, locus-specific, as well as allele-specific sequences. The H-2Dp nucleotide sequence is greater than 90% homologous to the H-2Ld and H-2Db genes and only approximate- ly 85% homologous to the H-2Dd gene. The K region and Qa region genes are less homologous. The 3' noncoding sequences appear to be region-specific. All of the previously described D region genes, Db, Ld, and Dd, possess the B2-SINE Alu-like repetitive sequence, as does Dp. Thus, this B2 repeat is a region-specific marker present in all D region genes studied so far. The additional polyadenylation site found in the H-2Dp gene starting at nucleotide 4671, which is homologous to non-D region sequences, as well as unique protein Dp coding sequences, make this gene an interesting model for studying the evolution of polymorphism and structure/function relationships in the class I gene family. |
