| First Author | Brickell PM | Year | 1983 |
| Journal | Nature | Volume | 306 |
| Issue | 5945 | Pages | 756-60 |
| PubMed ID | 6318117 | Mgi Jnum | J:57897 |
| Mgi Id | MGI:1345927 | Doi | 10.1038/306756a0 |
| Citation | Brickell PM, et al. (1983) Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse. Nature 306(5945):756-60 |
| abstractText | A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa/Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed. |
