| First Author | Chen L | Year | 2000 |
| Journal | Nature | Volume | 408 |
| Issue | 6815 | Pages | 936-43 |
| PubMed ID | 11140673 | Mgi Jnum | J:66410 |
| Mgi Id | MGI:1928431 | Doi | 10.1038/35050030 |
| Citation | Chen L, et al. (2000) Stargazing regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408(6815):936-43 |
| abstractText | Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin, the mutated protein, interacts with both AMPA receptor subunits and synaptic PDZ proteins, such as PSD-95. The interaction of stargazin with AMPA receptor subunits is essential for delivering functional receptors to the surface membrane of granule cells, whereas its binding with PSD-95 and related PDZ proteins through a carboxy-terminal PDZ-binding domain is required for targeting the AMPA receptor to synapses. Expression of a mutant stargazin lacking the PDZ-binding domain in hippocampal pyramidal cells disrupts synaptic AMPA receptors, indicating that stargazin-like mechanisms for targeting AMPA receptors may be widespread in the central nervous system. |
