| Type | MGI:General | Description | in culture, primary hepatocytes isolated from homozygous mice fail to clear [13C]acetaldehyde (ACE), a toxic intermediate product from ethanol metabolism, unlike wild-type controls homozygotes display slower ACE clearance after exposure to low-dose ethanol (2 g/kg) and fail to clear serum ACE after intermediate- (4 g/kg) or high-dose ethanol challenge (8 g/kg), unlike wild-type controls |
