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Protein Coding Gene : Dync2i2 dynein 2 intermediate chain 2

Primary Identifier  MGI:1919070 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  71820
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in cilium assembly and intraciliary retrograde transport. Located in cytoskeleton and filopodium. Part of cytoplasmic dynein complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Orthologous to human DYNC2I2 (dynein 2 intermediate chain 2).
PHENOTYPE: Mice homozygous for a null allele exhibit midgestational lethality, embryonic growth retardation, open brain and neural tube, microphthalmia, wider limb paddles, polydactyly, defects in retrograde ciliary protein trafficking and Hedgehog signaling, and stumpy cilia. [provided by MGI curators]
  • synonyms:
  • Dync2i2,
  • 3200002I06Rik,
  • RIKEN cDNA 3200002I06 gene,
  • Wdr34,
  • dynein 2 intermediate chain 2,
  • WD repeat domain 34

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For