| Primary Identifier | MGI:2147032 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 106759 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables signaling adaptor activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of cytokine production. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of lymphocyte activation. Located in cytosol and mitochondrion. Is expressed in brain and genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (TIR domain containing adaptor molecule 1). PHENOTYPE: Homozygous null mice are viable but exhibit abnormalities of the innate immune system. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
