| Primary Identifier | IPR021605 | Type | Domain |
| Short Name | CFIA_Pcf11_C |
| description | This entry represents the Clp1-interacting domain of Pcf11, found towards the C-terminal end of these proteins.PCF11 is a subunit and essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination [, , ]. It has been reported that PCF11-mediated termination is essential for vertebrate development and its own levels are maintained by an auto-regulatory mechanism involving premature termination of its transcript []. PCF11 binds to Clp1, another subunit of CFIA whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery [, ]. |
