| First Author | Obara N | Year | 1997 |
| Journal | Anat Embryol (Berl) | Volume | 195 |
| Issue | 2 | Pages | 193-202 |
| PubMed ID | 9045989 | Mgi Jnum | J:39148 |
| Mgi Id | MGI:86530 | Doi | 10.1007/s004290050038 |
| Citation | Obara N, et al. (1997) Distribution of the neural cell adhesion molecule (NCAM) during pre- and postnatal development of mouse incisors. Anat Embryol (Berl) 195(2):193-202 |
| abstractText | Developmental changes in the distribution of the neural cell adhesion molecule (NCAM) were investigated in mouse incisors by means of the indirect immunofluorescence method. During the prenatal stages of development, NCAM was predominantly found in the dental follicle, but not in the dental papilla; the results were analogous to the distribution of NCAM during molar development. After birth, the expression of NCAM continued in the tissue between the enamel organ and the alveolar bone on the labial aspect. In contrast, the follicular tissue covering the lingual aspect of the incisor gradually lost NCAM immunoreactivity from its outer zone as it differentiated into the highly organized periodontal ligament. The intermediate zone of the ligament continued to express NCAM-immunoreactivity even in mice of 6 weeks of age. This pattern of NCAM expression was different from that found in molar teeth, where the organized peridontal ligament was NCAM-negative. The dental pulp, in which we previously reported that an NCAM-positive area appeared at later stages of molar tooth development, did not express NCAM immunoreactivity even at the latest stage of development covered in this study. These differences in the distribution of NCAM between the incisors and the molars might be related to the fact that rodent incisors continue to grow throughout the life of the animal. |
