| Primary Identifier | MGI:1096337 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 270190 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables axon guidance receptor activity. Involved in several processes, including dendritic spine morphogenesis; detection of temperature stimulus involved in sensory perception of pain; and negative regulation of satellite cell differentiation. Acts upstream of or within several processes, including axonogenesis; ephrin receptor signaling pathway; and optic nerve morphogenesis. Located in several cellular components, including axon; filopodium tip; and membrane raft. Is active in glutamatergic synapse. Is expressed in several structures, including 1st branchial arch; brain; sensory organ; urogenital sinus; and vascular system. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human EPHB1 (EPH receptor B1). PHENOTYPE: Mice homozygous for disruptions of this gene display marked reductions of the ipsilateral optic tract. Homozygotes for one null allele show reduced corticospinal tract and abnormal anterior commissure axon crossing. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
