| Primary Identifier | MGI:2153181 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 140483 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables N-methyltransferase activity. Predicted to be involved in S-adenosylmethionine metabolic process; histamine catabolic process; and methylation. Predicted to be located in centrosome; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive intellectual developmental disorder 51; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit elevated histamine levels in the brain, increased aggression, hypoactivity and altered sleep-wake cycle. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
