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Protein Coding Gene : Smc2 structural maintenance of chromosomes 2
Primary Identifier  MGI:106067 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  14211
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables chromatin binding activity and single-stranded DNA binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Acts upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Located in condensed nuclear chromosome. Part of condensin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2).
PHENOTYPE: Homozygous null mice die embryonically. [provided by MGI curators]
  • synonyms:
  • 5730502P04Rik,
  • RIKEN cDNA 5730502P04 gene,
  • fibroblast growth factor inducible 16,
  • structural maintenance of chromosomes 2,
  • Smc2,
  • MGD-MRK-33751,
  • CAP-E,
  • MGI:1915197,
  • expressed sequence AW545314,
  • MGI:2140588,
  • Fin16,
  • MGI:2140211,
  • expressed sequence AI255214,
  • AW545314,
  • SMC2 structural maintenance of chromosomes 2-like 1 (yeast),
  • Smc2l1,
  • AI255214
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