First Author | Harizi H | Year | 2007 |
Journal | J Neuroimmunol | Volume | 189 |
Issue | 1-2 | Pages | 59-68 |
PubMed ID | 17658621 | Mgi Jnum | J:128970 |
Mgi Id | MGI:3768450 | Doi | 10.1016/j.jneuroim.2007.06.019 |
Citation | Harizi H, et al. (2007) Marked genetic differences in the regulation of blood glucose under immune and restraint stress in mice reveals a wide range of corticosensitivity. J Neuroimmunol 189(1-2):59-68 |
abstractText | Male and female mice from different control strains (C57BL/6, DBA/2, BALB/c) and the nonobese diabetic (NOD) strain, a spontaneous model of type 1 diabetes, were subjected to various stressors (restraint, lipopolysaccharide or interleukin-1 injection). Significant differences were measured among strains in blood glucose, insulin and corticosterone levels and, for restraint, IL-6. Addition of dexamethasone, a glucocorticoid receptor agonist, to inhibit the expression of several proteins by LPS-stimulated bone marrow-derived macrophages in vitro showed a gradient among control strains: C57BL/6>DBA/2>BALB/c corroborating the pattern of corticosensitivity suggested by their stress-induced glucose responses at the systemic level. |