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Protein Coding Gene : Klf11 Kruppel-like transcription factor 11

Primary Identifier  MGI:2653368 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  194655
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables DNA-binding transcription factor activity. Involved in negative regulation of DNA-templated transcription. Predicted to be located in cytosol; focal adhesion; and nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and sensory organ. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to human KLF11 (KLF transcription factor 11).
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile, show normal hematopoiesis, growth and development, and display no evidence of increased tumor formation following gamma-irradiation. [provided by MGI curators]
  • synonyms:
  • MGI:1196399,
  • Klf11,
  • Tieg2b,
  • TGFB inducible early growth response 3,
  • TGFB inducible early growth response 2,
  • Tieg2,
  • D12Ertd427e,
  • Kruppel-like transcription factor 11,
  • Tieg3,
  • MGI:2653358,
  • DNA segment, Chr 12, ERATO Doi 427, expressed

Features --> Cross References

Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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