Primary Identifier | IPR034818 | Type | Family |
Short Name | DUOX2 |
description | This entry represents dual oxidase 2 (DUOX2). DUOX1 and DUOX2 are isoenzymes that belong to the family of NADPH oxidases (Nox) []. They function as calcium-dependent NADPH oxidases producing hydrogen peroxide (H2O2) which is required for thyroid hormone biosynthesis []and the activity of lactoperoxidase (LPO) []. Duox2 is activated by activation of protein kinase C (PKC) and can be suppressed by thyroglobulin (Tg) [, ]. |