| First Author | Xu ZP | Year | 1998 |
| Journal | Dev Genet | Volume | 23 |
| Issue | 4 | Pages | 259-63 |
| PubMed ID | 9883578 | Mgi Jnum | J:51695 |
| Mgi Id | MGI:1321462 | Doi | 10.1002/(SICI)1520-6408(1998)23:4<259::AID-DVG1>3.0.CO;2-W |
| Citation | Xu ZP, et al. (1998) PAX6 intronic sequence targets expression to the spinal cord. Dev Genet 23(4):259-63 |
| abstractText | PAX6, a member of the family of highly conserved paired-box and homeobox genes, is highly conserved at both the protein and DNA levels. A conserved 216-bp Pax6 intron 4 sequence was found in human, mouse, and quail. Our transgenic mice experiments indicated that when under control of the human PAX6 promoter, the human 216-bp conserved sequence (ele4H) functioned as a spinal cord-specific enhancer. This enhancer can drive lacZ expression at the thoracic and lumbar levels of the spinal cord only when linked to a functional PAX6 promoter. These studies also suggested that PAX6 was not only conserved at the functional level, but at the transcriptional level as well. |
