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Allele : Tg(H2-K<b>-Tcrd57.9,Tcrg57.9)#Gks transgene insertion, Gek-Kee Sim

Primary Identifier  MGI:6451151 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(H2-K-Tcrd57.9,Tcrg57.9)#Gks
Strain of Origin  (C57BL/6 x DBA/2)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  The rearranged Vgamma6-Jgammal-Cgammal Tcrg gene from mycrobacterial antigen-specific T cell hybridoma 57.9 was cut to remove the silencer element 3' of the Cgamma1 segment. The rearranged Vdelta1-Jdelta2-Cdelta Tcrd gene from the same hybridoma was cloned downstream of the H2-Kb promoter, followed by beta globin exon 2, intron 2, exon 3 and poly(A) signal and the Igh enhancer. The gamma and delta constructs were co-injected into fertilized eggs. Nine different transgenic mouse lines (52, 56, 74, 77, 78, 114, 115, 131, 134) were established.
  • mutations:
  • Insertion
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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3 Publication categories

Trail: Allele