| Primary Identifier | IPR011162 | Type | Homologous_superfamily |
| Short Name | MHC_I/II-like_Ag-recog |
| description | Major Histocompatibility Complex (MHC) glycoproteins are heterodimeric cell surface receptors that function to present antigen peptide fragments to T cells responsible for cell-mediated immune responses. MHC molecules can be subdivided into two groups on the basis of structure and function: class I molecules present intracellular antigen peptide fragments (~10 amino acids) on the surface of the host cells to cytotoxic T cells; class II molecules present exogenously derived antigenic peptides (~15 amino acids) to helper T cells. MHC class I and II molecules are assembled and loaded with their peptide ligands via different mechanisms. However, both present peptide fragments rather than entire proteins to T cells, and are required to mount an immune response.This superfamily represents MHC class I and II-like antigen-recognition domains from:MHC class II, N-terminal domains of alpha and beta chains []MHC class I, alpha-1 and alpha-2 domains []MHC class I related proteins, such as gammadelta T-cell ligand [], Ulbp3 [], Fc (IgG) receptor (alpha-1 and -2 domains) [], CD1 (alpha-1 and -2 domains) [], zinc-alpha-2-glycoprotein ZAG (fat depleting factor) []Immunomodulatory protein m144, alpha-1 and alpha-2 domains []Haemochromatosis protein Hfe, alpha-1 and alpha-2 domains []NK cell ligand RAE-1 beta []Endothelial protein C receptor (phospholipid-binding protein) [] |
