| First Author | Roberts RG | Year | 1996 |
| Journal | Nat Genet | Volume | 13 |
| Issue | 2 | Pages | 223-6 |
| PubMed ID | 8640231 | Mgi Jnum | J:33275 |
| Mgi Id | MGI:80755 | Doi | 10.1038/ng0696-223 |
| Citation | Roberts RG, et al. (1996) Characterization of DRP2, a novel human dystrophin homologue. Nat Genet 13(2):223-6 |
| abstractText | The currently recognised dystrophin protein family comprises the archetype, dystrophin, its close relative, utrophin or dystrophin-related protein (DRP), and a distantly related protein known as the 87K tyrosine kinase substrate. During the course of a phylogenetic study of sequences encoding the characteristic C-terminal domains of dystrophin-related proteins, we identified an unexpected novel class of vertebrate dystrophin-related sequences. We term this class dystrophin-related protein 2 (DRP2), and suggest that utrophin/DRP be renamed DRP1 to simplify future nomenclature. DRP2 is a relatively small protein, encoded in man by a 45 kb gene localized to Xq22. It is expressed principally in the brain and spinal cord, and is similar in overall structure to the Dp116 dystrophin isoform. The discovery of a novel relative of dystrophin substantially broadens the scope for study of this interesting group of proteins and their associated glycoprotein complexes. |
