| Primary Identifier | IPR030615 | Type | Family |
| Short Name | DRP2 |
| description | The Dihydropyrimidinase Related Protein (DRP) family, also known as collapsin response mediator proteins (CRMPs), consists of five members, DRP1-5. Members of this family have been proposed to be part of the semaphorins signal transduction pathway involved in neurite outgrowth, and neuronal differentiation and death [, ]. They are cytosolic proteins highly expressed throughout brain development [].Dihydropyrimidinase-related protein 2 (DRP2), also known as CRMP2 or ULIP2, mediates axonogenesis, axon outgrowth and neuronal polarity, as well as migration [, , , ]. DRP2/CRMP2 modulates neurite length through direct binding to tubulin and promoting microtubule polymerisation [, , ]. It interacts with numerous binding partners to affect microtubule dynamics, endocytosis, synaptic assembly, calcium channel regulation and neurotransmitter release [, , ].DRP2/CRMP2 is expressed widely in neuronal tissues, and is also expressed in non-neuronal cells, including fibroblasts []and T-cells [, ], which suggests roles in proliferation and immune function. Two variants of CRMP2 have been reported, a long and short form, with a common core polypeptide but different N-terminal domains that are products of alternative mRNA splicing []. The balance between the expression of the two subtypes is involved in the control of axonal branching and elongation. |
