| Primary Identifier | MGI:5689425 | Allele Type | Transgenic |
| Attribute String | Epitope tag, Inserted expressed sequence, Reporter | Gene | Tg(LONP1-mt-ND4*,-mCherry*)#Jguy |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| description | The transgene is maintained without integration into the host genome. |
| molecularNote | The mitochondria-targeted self-complementary adeno-associated virus (AAV) transgene contained the human mitochondrial heavy-strand promoter driving mitochondrial expression of the FLAG tagged human mt-ND4 with the substitution of A for G taht results in an arginine-to-histidine substitution and mitochondrial mCherry with the substitution A for C. This mutation is responsible for Leber hereditary optic neuropathy (LHON). There are two stop codons between the genes. The pound symbol (#) is used when no line is specified and/or lines are pooled. |
