| First Author | Yuan Q | Year | 1991 |
| Journal | Biochem Biophys Res Commun | Volume | 176 |
| Issue | 3 | Pages | 1443-9 |
| PubMed ID | 1710115 | Mgi Jnum | J:32336 |
| Mgi Id | MGI:79836 | Doi | 10.1016/0006-291x(91)90448-g |
| Citation | Yuan Q, et al. (1991) Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine. Biochem Biophys Res Commun 176(3):1443-9 |
| abstractText | A cDNA clone encoding the N-terminal sequence of the murine integrin beta 7 subunit, a novel member of the leukocyte cell adhesion molecule subset (Leu-CAM), has been isolated. An N-terminal region of 13 contiguous amino acids deduced from the cDNA shows complete identity with the N-terminus of the 120 kDa subunit of the M290 antigen, a surface molecule found highly expressed on mouse intestinal intraepithelial lymphocytes (IEL). This unexpected result focuses two previously unconnected areas of research and suggests that integrins may have a special role to play in the defence of the gut mucosa. |
