Primary Identifier | MGI:5532653 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Tcra |
Transmission | Germline | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting construct inserted between the Jalpha and C alpha exons four polyadenylation sequences, a 1.8 kb of upstream regulatory sequence, the Valpha14 promoter, a leader sequence, a floxed stop cassette, the sequence for the Valpha14 and Jalpha18 invariant (Valpha14i) arrangement expressed in most NKT cells and a 0.2 kb intronic sequence. This insertion abolishes TCRalpha expression. |