| First Author | Herndler-Brandstetter D | Year | 2018 |
| Journal | Immunity | Volume | 48 |
| Issue | 4 | Pages | 716-729.e8 |
| PubMed ID | 29625895 | Mgi Jnum | J:272661 |
| Mgi Id | MGI:6284459 | Doi | 10.1016/j.immuni.2018.03.015 |
| Citation | Herndler-Brandstetter D, et al. (2018) KLRG1(+) Effector CD8(+) T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity 48(4):716-729.e8 |
| abstractText | Protective immunity against pathogens depends on the efficient generation of functionally diverse effector and memory T lymphocytes. However, whether plasticity during effector-to-memory CD8(+) T cell differentiation affects memory lineage specification and functional versatility remains unclear. Using genetic fate mapping analysis of highly cytotoxic KLRG1(+) effector CD8(+) T cells, we demonstrated that KLRG1(+) cells receiving intermediate amounts of activating and inflammatory signals downregulated KLRG1 during the contraction phase in a Bach2-dependent manner and differentiated into all memory T cell linages, including CX3CR1(int) peripheral memory cells and tissue-resident memory cells. "ExKLRG1" memory cells retained high cytotoxic and proliferative capacity distinct from other populations, which contributed to effective anti-influenza and anti-tumor immunity. Our work demonstrates that developmental plasticity of KLRG1(+) effector CD8(+) T cells is important in promoting functionally versatile memory cells and long-term protective immunity. |
