| First Author | Guzmán CB | Year | 2009 |
| Journal | Behav Brain Res | Volume | 199 |
| Issue | 2 | Pages | 355-9 |
| PubMed ID | 19162088 | Mgi Jnum | J:146153 |
| Mgi Id | MGI:3836838 | Doi | 10.1016/j.bbr.2009.01.005 |
| Citation | Guzman CB, et al. (2009) Sex-dependent effect of cyclooxygenase-2 inhibition on mouse spatial memory. Behav Brain Res 199(2):355-9 |
| abstractText | Cyclooxygenase (COX)-2 is constitutively expressed in neurons of the hippocampus and neocortex. Therefore, non-steroidal anti-inflammatory drugs (NSAIDs) targeting inflammation-induced COX-2 in the periphery and the central nervous system may also affect cognitive function mediated by basal COX-2 activity. We report that systemic administration of the selective COX-2 inhibitor NS-398 6h prior to behavioral assessment does not influence spatial acquisition or retention in male C57BL/6J mice. However, we observed impaired spatial retention in female mice treated with NS-398, suggesting a sex-dependent role of COX-2 in spatial memory of mice. |
