| Primary Identifier | IPR008047 | Type | Family |
| Short Name | MCM_4 |
| description | The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm4 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring []. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [, , ]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [].The components of the MCM2-7 complex are: .DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, DNA replication licensing factor MCM5, DNA replication licensing factor MCM6, DNA replication licensing factor MCM7, Mcm4 is thought to play a pivotal role in ensuring DNA replication occursonly once per cell cycle. Phosphorylation of Mcm4 dramatically reduces itsaffinity for chromatin - it has been proposed that this cell cycle-dependentphosphorylation is the mechanism that inactivates the MCM complex from lateS phase through mitosis, thus preventing illegitimate DNA replication during that period of the cell cycle []. |
