| First Author | Ait-Oufella H | Year | 2008 |
| Journal | Arterioscler Thromb Vasc Biol | Volume | 28 |
| Issue | 8 | Pages | 1429-31 |
| PubMed ID | 18467644 | Mgi Jnum | J:159811 |
| Mgi Id | MGI:4452467 | Doi | 10.1161/ATVBAHA.108.169078 |
| Citation | Ait-Oufella H, et al. (2008) Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol 28(8):1429-31 |
| abstractText | OBJECTIVE: To study the role of Mer receptor tyrosine kinase (mertk) in atherosclerosis. METHODS AND RESULTS: We irradiated and reconstituted atherosclerosis-susceptible C57Bl/6 low-density lipoprotein receptor-deficient female mice (ldlr(-/-)) with either a mertk(+/+) or mertk(-/-) (tyrosine kinase-defective mertk) bone marrow. The mice were put on high-fat diet for either 8 or 15 weeks. Mertk deficiency led to increased accumulation of apoptotic cells within the lesions, promoted a proinflammatory immune response, and accelerated lesion development. CONCLUSIONS: Mertk expression by bone marrow-derived cells is required for the disposal of apoptotic cells and controls lesion development and inflammation. |
