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Allele : Kmo<tm1c(KOMP)Wtsi> kynurenine 3-monooxygenase; targeted mutation 1c, Wellcome Trust Sanger Institute

Primary Identifier  MGI:5796292 Allele Type  Targeted
Attribute String  Conditional ready Gene  Kmo
Transmission  Germline Strain of Origin  C57BL/6N
Is Recombinase  false Is Wild Type  false
Project Collection  KOMP-CSD
molecularNote  The L1L2_Bact_P cassette was inserted at position 175470673 of Chromosome 1 upstream of exon 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 4 at position 175471397. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, removing the lacZ sequences and the neomycin selection cassette. Exon 4 remains flanked by loxP sites.
  • mutations:
  • Insertion
  • synonyms:
  • Kmo<FRT-deleted>,
  • Kmo<tm1c(KOMP)Wtsi/flox(ex5)>,
  • Kmo<FRT-deleted>,
  • Kmo<tm1c(KOMP)Wtsi/flox(ex5)>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories

Trail: Allele