Primary Identifier | MGI:95768 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 14674 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and regulation of blood pressure. Acts upstream of or within several processes, including Rho protein signal transduction; branching involved in blood vessel morphogenesis; and platelet activation. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; genitourinary system; gut gland; nervous system; and sensory organ. Orthologous to human GNA13 (G protein subunit alpha 13). PHENOTYPE: Mice homozygous for a targeted null or with an endothelial specific conditional mutation fail to develop an organized vascular system in the yolk sac, show impaired vascular development in some vascular beds in the embryo proper, and die during organogenesis. [provided by MGI curators] |