| First Author | Kieslinger M | Year | 2005 |
| Journal | Dev Cell | Volume | 9 |
| Issue | 6 | Pages | 757-67 |
| PubMed ID | 16326388 | Mgi Jnum | J:104946 |
| Mgi Id | MGI:3613214 | Doi | 10.1016/j.devcel.2005.10.009 |
| Citation | Kieslinger M, et al. (2005) EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Dev Cell 9(6):757-67 |
| abstractText | Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/TCF:beta-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts. |
