Primary Identifier | MGI:6507739 | Allele Type | Targeted |
Attribute String | Inducible, Recombinase | Gene | Six3 |
Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
Induced With | tamoxifen | Is Recombinase | true |
Is Wild Type | false |
description | The version of this allele that contains the neomycin selection cassette, Six3tm4(cre/ERT1)Gco, has been analyzed. |
molecularNote | A cre/ERT2 fusion gene is used to replace part of exon 1, in frame 22 nucleotides downstream from the start codon. A floxed selection cassette is inserted in exon 1 downstream of cre/ERT2. Cre-mediated recombination removed the floxed neo cassette. |