| First Author | Boismenu R | Year | 2000 |
| Journal | J Leukoc Biol | Volume | 67 |
| Issue | 3 | Pages | 267-78 |
| PubMed ID | 10733087 | Mgi Jnum | J:60941 |
| Mgi Id | MGI:1354109 | Doi | 10.1002/jlb.67.3.267 |
| Citation | Boismenu R, et al. (2000) Insights from mouse models of colitis. J Leukoc Biol 67(3):267-78 |
| abstractText | Emerging studies using mouse models of experimental colitis are defining the nature of the immunological disturbances that initiate inflammation and destruction of the intestine. A better understanding of disease-promoting and -suppressing CD4+ T cells is providing insight into the mechanisms controlling immune responses within the intestinal compartment. Moreover, a role for distinct T cell populations, including intraepithelial gammadelta T cells, in maintaining the physical integrity of the intestine was suggested by recent studies. Cytokine gene-knockout mice and anti-cytokine treatments remain important tools to define the pro- and anti-inflammatory functions of cytokines. These advances are fostering the design and evaluation of new therapeutic approaches that may eventually be applied to treat human inflammatory bowel disease. |
