| First Author | Wang JY | Year | 1984 |
| Journal | Cell | Volume | 36 |
| Issue | 2 | Pages | 349-56 |
| PubMed ID | 6319018 | Mgi Jnum | J:7292 |
| Mgi Id | MGI:55763 | Doi | 10.1016/0092-8674(84)90228-9 |
| Citation | Wang JY, et al. (1984) The mouse c-abl locus: molecular cloning and characterization. Cell 36(2):349-56 |
| abstractText | The mouse c-abl gene, part of the sequence of which was captured in Moloney murine leukemia virus to generate the transforming gene (v-abl) of the Abelson murine leukemia virus, has been isolated and characterized. The c-abl locus spans 40 kb in the mouse genome with the v-abl homologies distributed in no less than ten clusters along 25 kb of the cloned DNA. Partial sequence of the v-abl homologous regions indicates that v-abl derived from c-abl mainly by splicing of multiple exons of the c-abl gene. The c-abl sequences can be subdivided into two regions: a tyrosine kinase coding sequence distributed among eight small clusters on the 5' end of the gene and a C-terminal portion consisting of one small and one large cluster, which are needed neither for the tyrosine kinase activity nor for the transforming ability of v-abl. Apparent exon/intron boundaries in the homologous kinase-coding regions of c-abl and c-src are at different locations. |
