| First Author | Klinken SP | Year | 1989 |
| Journal | J Virol | Volume | 63 |
| Issue | 5 | Pages | 2411-4 |
| PubMed ID | 2539530 | Mgi Jnum | J:9707 |
| Mgi Id | MGI:58164 | Doi | 10.1128/jvi.63.5.2411-2414.1989 |
| Citation | Klinken SP, et al. (1989) Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci. J Virol 63(5):2411-4 |
| abstractText | The susceptibility to tumors induced by raf and raf/myc retroviruses was investigated in BALB/c, C57BL/6, (BALB/c x C57BL/6)F1 and (BALB/c x C57BL/6) backcross mice. Newborn mice were susceptible to neoplasms generated by both viruses, but resistance to raf-induced leukemia developed rapidly in all mice as they matured. Older C57BL/6 mice were also resistant to raf/myc lymphomas, whereas BALB/c mice remained susceptible to the virus at all ages, indicating that different genes control susceptibility to raf and raf/myc tumors. From these data and the susceptibility of C x B recombinant inbred strains, it appears that very few genes (perhaps even a single gene) may govern susceptibility to raf/myc lymphomas and that resistance is the dominant trait. |
