| First Author | Nigro V | Year | 1997 |
| Journal | Hum Mol Genet | Volume | 6 |
| Issue | 4 | Pages | 601-7 |
| PubMed ID | 9097966 | Mgi Jnum | J:39515 |
| Mgi Id | MGI:86909 | Doi | 10.1093/hmg/6.4.601 |
| Citation | Nigro V, et al. (1997) Identification of the Syrian hamster cardiomyopathy gene. Hum Mol Genet 6(4):601-7 |
| abstractText | The BIO14.6 hamster is a widely used model for autosomal recessive cardiomyopathy. These animals die prematurely from progressive myocardial necrosis and heart failure. The primary genetic defect leading to the cardiomyopathy is still unknown. Recently, a genetic linkage map localized the cardiomyopathy locus on hamster chromosome 9qa2.1-b1, excluding several candidate genes. We now demonstrate that the cardiomyopathy results from a mutation in the delta-sarcoglycan gene that maps to the disease locus. This mutation was completely coincident with the disease in backcross and F2 pedigrees. This constitutes the first animal model identified for human sarcoglycan disorders. |
