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Allele : Pla2g4a<tm1.1Cect> phospholipase A2, group IVA (cytosolic, calcium-dependent); targeted mutation 1.1, Charles E Chalfant

Primary Identifier  MGI:7516735 Allele Type  Targeted
Gene  Pla2g4a Transmission  Germline
Strain of Origin  129 Is Recombinase  false
Is Wild Type  false
molecularNote  The targeting construct inserted into intron three a loxP site-flanked puromycin resistance gene followed by a premature stop codon and a modified exon 4 with the mutation responsible for the amino acid substitution of arginine, lysine, and arginine to alanine at positions 57, 58, and 59 (R57A, K58A, and R59A) in the C1P binding site. Cre-mediated recombination removed the selection cassette and stop.
  • mutations:
  • Insertion
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

4 Publication categories

Trail: Allele