| Primary Identifier | IPR023535 | Type | Family |
| Short Name | TC-AMP_synthase |
| description | This entry represents the threonylcarbamoyl-AMP synthase, includding RimN or YrdC (also known as TsaC) [], which is involved in the biosynthesis of N6-threonyl-carbamoyl-adenosine (t6A) modified tRNA. This is a universal modification, found at position 37 of ANN decoding tRNAs. Analysis shows that YrdC binds ATP and preferentially binds tRNA-Thr lacking the t6A modification []. Furthermore YrdC has been shown to have threonine-dependent ATPase activity that generates AMP []. YrdC (TsaC) and proteins YgjD (TsaD), YjeE (TsaE), and YeaZ (TsaB), are necessary and sufficient for t6A biosynthesis in vitro, and may constitute a complex. |
