| Primary Identifier | MGI:1919742 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 233789 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable diacylglycerol-dependent serine/threonine kinase activity and telomeric DNA binding activity. Predicted to be involved in several processes, including nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; phosphatidylinositol phosphate biosynthetic process; and regulation of telomere maintenance. Predicted to act upstream of or within DNA repair. Located in chromatoid body. Is expressed in cerebral cortex; early embryo; and germ cell of testis. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase). PHENOTYPE: Mice homozygous for a gene trap allele exhibit early embryonic lethality. Mice heteroygous for a gene trap allele exhibit abnormal tooth development, chronic inflammation, increased body weight, increased incidence of tumor formation and premature death. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
