| Primary Identifier | MGI:2183229 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Tnfrsf11b |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin selection cassette into exon 2 replaced sequence encoded the first 93 residues of the mature protein. This targeting strategy eliminated the first two cysteine-rich domains, which are essential for function, and introduced an in-frame stop codon. Northern blot analysis of total hepatic RNA confirmed the absence of transcript in homozygous mutant mice. |
