| Type | function | Description | Plays a role in DNA damage repair as component of the ASCC complex (By similarity). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (By similarity). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (By similarity). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (By similarity). As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes (By similarity). |
