| First Author | Ehling M | Year | 2013 |
| Journal | Development | Volume | 140 |
| Issue | 14 | Pages | 3051-61 |
| PubMed ID | 23785053 | Mgi Jnum | J:198633 |
| Mgi Id | MGI:5498585 | Doi | 10.1242/dev.093351 |
| Citation | Ehling M, et al. (2013) Notch controls retinal blood vessel maturation and quiescence. Development 140(14):3051-61 |
| abstractText | Blood vessels form a hierarchically organized network of arteries, capillaries and veins, which develops through a series of growth, pruning and maturation processes. In contrast to the rapidly increasing insight into the processes controlling vascular growth and, in particular, endothelial sprouting and proliferation, the conversion of immature vessels into a fully functional, quiescent vasculature remains little understood. Here we used inducible, cell type-specific genetic approaches to show that endothelial Notch signaling is crucial for the remodeling of veins and the perivenous capillary plexus, which occurs after the completion of the initial angiogenic growth phase in the retina of adolescent mice. Mutant vessels showed ectopic proliferation and sprouting, defective recruitment of supporting mural cells, and failed to downregulate the expression of VEGF receptors. Surprisingly, by contrast Notch was dispensable in the endothelium of remodeling postnatal arteries. Taken together, our results identify key processes contributing to vessel remodeling, maturation and the acquisition of a quiescent phenotype in the final stage of developmental angiogenesis. |
